Ketamine’s Antidepressant Effect May Depend on Opioid System

Previous studies of ketamine have focused on glutamate, but the new finding showing activation of opioid receptors shows why repeated use of ketamine may produce tolerance and addiction. The antidepressant effects of ketamine appear to depend on activation of the brain’s opioid receptors, underscoring the drug’s addictive potential, according to a report published this week

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